This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Elmergib University, Faculty of Medical Technology , Msallata , Libya
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4 , Belgrade , Serbia
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4 , Belgrade , Serbia
University of Misurata, Faculty of Nursing and Health Sciences, Alshowahda Park, 3rd Ring Road , Misurata , Libya
University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Njegoševa 12 , Belgrade , Serbia
University of Belgrade, Institute for the Application of Nuclear Energy INEP, Banatska 31b , Belgrade , Serbia
University of Belgrade, Institute for the Application of Nuclear Energy INEP, Banatska 31b , Belgrade , Serbia
University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4 , Belgrade , Serbia
University of Belgrade, Institute for the Application of Nuclear Energy INEP, Banatska 31b , Belgrade , Serbia
Vaccinium myrtillus fruits and leaves show significant economic importance due to their application in food, functional food, pharmaceutical, cosmetic, and healthcare products. Bilberry leaves contain valuable components, such as phenolic acids, flavonoids, procyanidins, anthocyanins, fatty acids, and dietary fibers. The mentioned compounds possess various biological potentials, including antioxidant, anti-inflammatory, antimicrobial, regenerative, astringent, lipid-lowering, and anti-diabetic properties. With the aim of improving storage stability, biodistribution, and bioavailability, as well as providing controlled release of bioactive compounds, V. myrtillus extract was encapsulated in the liposomal vesicles, and their storage stability and stability after UV irradiation were monitored. Vesicle size, polydispersity index (PDI), and zeta potential were determined in the 60-day storage study at 4°C. The liposome size varied in a narrow range. PDI values were between 0.294 and 0.338 (for the non-treated sample) and 0.249 and 0.437 (for the UV-irradiated sample). The zeta potential was -5.02 mV on the 1st day and -9.16 mV on the 60th day for non-treated liposomes, while for UV-irritated, the zeta potential amounted to -3.93 mV on the 1st day and -8.22 mV on the 60th day. In both types of the sample, there was no significant change in the vesicle size during storage, while the zeta potential (absolute value) increased. Additionally, the PDI value increased in the UV-irradiated liposomes. The beneficial effects of bioactive principles from bilberry leaf on human health highlight the application of liposomes as a carrier for its extract and their potential implementation in food, functional food, pharmaceutical, and cosmetic formulations.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
