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Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4 , Belgrade , Serbia
Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b , Belgrade , Serbia
Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12 , Belgrade , Serbia
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4 , Belgrade , Serbia
Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b , Belgrade , Serbia
The aim of the present study was the characterization of fumitory extract-loaded liposomal vesicles after UV irradiation via the determination of encapsulation efficiency, size, polydispersity index (PDI), zeta potential, mobility, and conductivity. The encapsulation efficiency was the same before and after UV irradiation (>69%). Particle size and PDI of the UV-irradiated liposomes with fumitory extract were 294.2±4.1 nm and 0.387±0.011, respectively. The zeta potential after UV irradiation was -5.51±0.4 mV. Mobility and conductivity of the obtained liposomal particles were -0.429±0.012 µmcm/Vs and 0.468±0.005 mS/cm, respectively. The results indicate the existence of nanoparticles and a non-uniform system, while negative zeta potential value is related to the organization of phospholipids. Since UV irradiation did not cause significant changes in all mentioned parameters of fumitory extract-loaded liposomes, it can be employed as a sterilization step in the preparation of liposomes.
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